Conservative structural motifs in the 3' untranslated region of SARS coronavirus
نویسندگان
چکیده
منابع مشابه
Structural insights into SARS coronavirus proteins.
The SARS coronavirus was identified as the pathogen of a global outbreak of SARS (severe acute respiratory syndrome) in 2003. Its large RNA genome encodes four structural proteins, sixteen non-structural proteins and eight accessory proteins. The availability of structures of SARS coronavirus macromolecules has enabled the elucidation of their important functions, such as mediating the fusion o...
متن کاملA phylogenetically conserved hairpin-type 3' untranslated region pseudoknot functions in coronavirus RNA replication.
Secondary and tertiary structures in the 3' untranslated region (UTR) of plus-strand RNA viruses have been postulated to function as control elements in RNA replication, transcription, and translation. Here we describe a 54-nucleotide (nt) hairpin-type pseudoknot within the 288-nt 3' UTR of the bovine coronavirus genome and show by mutational analysis of both stems that the pseudoknotted struct...
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15 صفحه اولSARS Coronavirus Detection Methods
Using clinical samples from patients with severe acute respiratory syndrome, we showed that the sensitivities of a quantitative reverse transcription-polymerase chain reaction (80% for fecal samples and 25% for urine samples) were higher than those of the polyclonal (50% and 5%) and monoclonal (35% and 8%) antibody-based nucleocapsid antigen capture enzyme-linked immunosorbent assays.
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2003
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.000661